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Digital slide: |
Case 7-1 Case 7-2 |
Species: |
Rat |
Strain/breeder: |
Wistar (CrLGlxBrlHan:WI) |
Sex: |
Male |
Age: |
Approx. 8 weeks |
Study type: |
14-day gavage study |
Treatment: |
VEGFR-antagonist |
Animal status: |
No abnormalities detected |
Clinical findings: |
None |
Organ(s): |
Kidneys |
Gross finding(s): |
none |
Staining: |
H&E (case 7/1), PAS (case 7/2) |
Literature: |
H.F. Dvorak (2003): How tumours make bad blood vessels and stroma. Am.J.Pathol. 162, 1747 - 1757 | H.F. Dvorak (2002): Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J.Clin.Oncol. 20, 4368 – 4380 | Feng D, Nagy J, Hipp J, Dvorak H, Dvorak A and. (1996) Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin. J Exp Med 183: 1981–198 |
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