 | |
| Digital slide(s): |
Case 4-1: Lung, H&E
Case 4-2: Lung, modified martius scarlet Blue |
| Species / breed: |
Wistar Rat, (SPF Glx/BRL/Han) |
| Sex: |
Female |
| Age: |
15 weeks |
| Study type: |
Toxicity Study with 2 Intravenous administrations at 21-day interval, followed by a 28-day recovery period |
| Treatment: |
Cytotoxic agent |
| Clinical findings: |
Late mortality of 2 high dose females (one death and one premature kill on day 26-Cycle 2).
Clinical signs: poor clinical status for a few days preceding death / premature kill with general pallor, decreased motor activity, prostration, pilo-erection, blepharoptosis (total or partial) and dyspnea. |
| Organ(s): |
Lung |
| Gross finding(s): |
Enlarged lungs with oedema and dark red discolouration or foci |
| Staining: |
H&E and modified Martius Scarlet Blue |
