European Society of Toxicologic Pathology (ESTP)
    European Society of Toxicologic Pathology
GTP meeting 2001: Case No 5
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Species: Rat
Strain/breeder: Crl:Wist Han
Sex: Male
Age: 15 Weeks
Study type: 26-Week oral toxicity study
Treatment: VEGF-receptor tyrosine kinase inhibitor
Animal status: Sacrifice before schedule after 7 weeks
Clinical findings: White discoloration and fracture of teeth
Organ(s): Teeth (incisors) and bone (femur/tibia)
Macroscopic
finding(s):
White discoloration and fracture of teeth
Staining: H&E
Case 5, Fig. 1
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Case 5, Fig. 2
Fig. 2 (130k)

Case 5, Fig. 3
Fig. 3 (94k)

Case 5, Fig. 4
Fig. 4 (126k)

Case 5, Fig. 5
Fig. 5 (118k)


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